CAS NO: | 54965-24-1 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
10 g | 电议 |
50 g | 电议 |
生物活性 | Tamoxifen Citrate (ICI 46474) is an orally active, selectiveestrogen receptor modulator(SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[1][2][3].Tamoxifen Citrate is a potentHsp90activator and enhances theHsp90molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectiousEBOV ZaireandMarburg (MARV)withIC50of 0.1 μM and 1.8 μM, respectively[5]. Tamoxifen Citrate activatesautophagyand inducesapoptosis[4].Tamoxifen Citrate also can induce gene knockout of CreER(T2) transgenic mouse[6]. | ||||||||||||||||
IC50& Target[1][4] |
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体外研究 (In Vitro) | Tamoxifen Citrate (ICI 46474) shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells[2]. | ||||||||||||||||
体内研究 (In Vivo) | The Tamoxifen Citrate-inducible gene knockout strategy has clear advantages in that expression of a gene can be ablated in adult mice at will in a tissue specific manner. To study the role of Med1 in adult heart, 7-week old TmcsMed1-/-mice are given a daily Iintraperitoneal injection of Tamoxifen Citrate at a dose of 65 mg/kg for 5 days and killed at selected intervals thereafter. qPCR analysis of RNA shows that the Med1 expression begin to decrease after 3 days of Tamoxifen Citrate injection (about 70% decrease), and by 5 days of injection, Med1 expression is almost non-detectable in the heart. Tamoxifen Citrate-inducible cardiac-specific disruption of Med1 (TmcsMed1-/-) in adult mice causes dilated cardiomyopathy[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 563.64 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C32H37NO8 | ||||||||||||||||
CAS 号 | 54965-24-1 | ||||||||||||||||
中文名称 | 他莫昔芬柠檬酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 50 mg/mL(88.71 mM;Need ultrasonic) Ethanol : 10 mg/mL(17.74 mM;Need ultrasonic) H2O : 1 mg/mL(1.77 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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