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GRP78-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GRP78-IN-3图片
CAS NO:2707510-30-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
GRP78-IN-3 是一种选择性Grp78 (HSPA5)抑制剂,IC50为 0.59 μM。GRP78-IN-3 对 HspA5 的选择性是 HspA9 的 7 倍 (IC50为 4.3 μM),是 HspA2 的 20 倍以上 (IC50为 13.9 μM)。
生物活性

GRP78-IN-3 is a selectiveGrp78 (HSPA5)inhibitor with anIC50of 0.59 μM. GRP78-IN-3 is 7-fold selective forHspA5compared to HspA9 (IC50of 4.3 μM) and >20-fold selective forHspA5compared to HspA2 (IC50of 13.9 μM)[1].

IC50& Target[1]

HSPA5

0.59 μM (IC50)

体外研究
(In Vitro)

GRP78-IN-3 (compound 8) is a potent small-molecule-competitive inhibitor of Hsp70 substrate binding. GRP78-IN-3 (0.1-100 μM) shows more potent inhibition efffects in a spheroid tumor model (U251 glioblastoma cells and H520 lung cancer cells)[1].

分子量

342.42

Formula

C17H18N4O2S

CAS 号

2707510-30-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.