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LDN-192960
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LDN-192960图片
CAS NO:184582-62-5
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
LDN-192960 是HaspinDYRK2的双重抑制剂,IC50值分别为 10 nM 和 48 nM。
生物活性

LDN-192960 is an inhibitor ofHaspinandDual-specificity Tyrosine-regulated Kinase 2 (DYRK2)withIC50s of 10 nM and 48 nM, respectively[1].

IC50& Target

IC50: 10 nM (Haspin); 48 nM (DYRK2)[1]

体外研究
(In Vitro)

LDN-192960 (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC50<1 μm), including clk1 (ic50=0.21 μM), DYRK1A (IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM)[1].
LDN-0192960 (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC50of 1.17 μM[2].
LDN-0192960 (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC50of 0.02 μM[2].

分子量

328.43

性状

Solid

Formula

C18H20N2O2S

CAS 号

184582-62-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month