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SOP1812
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SOP1812图片
CAS NO:2546091-70-5
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
SOP1812 是一种 naphthalene diimide (ND) 衍生物,具有抗肿瘤活性。SOP1812 能够与quadruplex arrangements (G4s)结合,并下调多个癌症基因通路。SOP1812 对 hTERT G4 和 HuTel21 具有很强的亲和力,其KD值分别为 4.9 和 28.4 nM。G4SOP1812 可用于癌症的研究。
生物活性

SOP1812 is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds toquadruplex arrangements (G4s), and down-regulates severalcancergene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 withKDvalues of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research ofcancer[1].

体外研究
(In Vitro)

SOP1812 (0-50 nM; 96 h) inhibits the proliferation of many cancer cells[1].
SOP1812 (0-800 nM; 6-24 h) shows great affinity to hTERT G4 and HuTel21 G4[1].
SOP1812 (40 nM; 6-24 h) affects Wnt/β-catenin, axon guidance, Hippo, MAPK and Rap1 pathways[1].

Cell Proliferation Assay[1]

Cell Line:MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines
Concentration:0-50 nM
Incubation Time:96 hours
Result:Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI50values of 1.3, 1.4, 5.9 and 2.6 nM, respectively.

Cell Viability Assay[1]

Cell Line:PANC-1 cells
Concentration:0, 100, 400 and 800 nM
Incubation Time:6 and 24 hours
Result:Binded to hTERT G4 and HuTel21 G4 withKDvalues of 4.9 and 28.4 nM, respectively.

Cell Viability Assay[1]

Cell Line:MIA PaCa-2 Cells
Concentration:40 nM
Incubation Time:6 and 24 hours
Result:Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways.
体内研究
(In Vivo)

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice[1].

Animal Model:Female athymic nude mice with MIA PaCa-2 xenografts[1]
Dosage:1 mg/kg
Administration:Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result:Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.
Animal Model:KPC mice with PDAC symptoms[1]
Dosage:1 mg/kg
Administration:Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result:Significantly extended survival of KPC mice and showed a better effect than gemcitabine.
分子量

791.98

性状

Solid

Formula

C45H57N7O6

CAS 号

2546091-70-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 200 mg/mL(252.53 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.2627 mL6.3133 mL12.6266 mL
5 mM0.2525 mL1.2627 mL2.5253 mL
10 mM0.1263 mL0.6313 mL1.2627 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。