Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs ofAglaia perviridis, and is a specificeIF4A-targeting translation inhibitor, with antitumor activity.

Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity^[1]. Episilvestrol is cytotoxic activity against several human cancer cell lines, such as Lu1, LNCaP, MCF-7 and HUVEC cells, with ED₅₀s of 3.8, 3.8, 5.5 and 15.3 nM, respectively^[2]. The GI₅₀s of Episilvestrol against the cell proliferation of NCI-H460 and MCF-7 cels are 17.96 nM and 17.96 nM after first test and 15.6 nM and 18.7 nM after 2 months via SRB assay. Episilvestrol also suppresses HK1 cells and EBV-positive C666.1 NPC cells^[3].

654.66

Solid

C₃₄H₃₈O₁₃

697235-39-5

• Others

• Plants
• Meliaceae
• Aglaia perviridisHiern

Room temperature in continental US; may vary elsewhere.

DMSO : 25 mg/mL(38.19 mM;Need ultrasonic)

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。