CAS NO: | 901787-88-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor ofeIF4E/eIF4G interactionand oftranslation initiation. (Z)-4EGI-1 effectively binds toeIF4Ewith anIC50of 43.5 μM and aKdvalue of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | (Z)-4EGI-1 (15-30 μM; 6 hours; CRL-2813 melanoma cells) treatment markedly reduces the expressions of the regulatory proteins: cyclin D1, cyclin E, and Survivin, while the expressions of housekeeping proteins such as β-Actin and α-Tubulin are not affected[1]. Western Blot Analysis[1]
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分子量 | 451.28 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H12Cl2N4O4S | ||||||||||||||||
CAS 号 | 901787-88-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(110.80 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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