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Briciclib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Briciclib图片
CAS NO:865783-99-9
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
ON 014185
产品介绍
Briciclib (ON 014185) 是一种 ON 013100 衍生物,具有靶作用于eIF4E对抗固体肿瘤的潜力。
生物活性

Briciclib (ON 014185) is a derivative of ON 013100, and has the potential in targetingeIF4Efor solid cancers.

IC50& Target

eIF4

 

体外研究
(In Vitro)

Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1].

Clinical Trial
分子量

474.42

性状

Solid

Formula

C19H23O10PS

CAS 号

865783-99-9

中文名称

布瑞西利

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 31 mg/mL(65.34 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.1078 mL10.5392 mL21.0784 mL
5 mM0.4216 mL2.1078 mL4.2157 mL
10 mM0.2108 mL1.0539 mL2.1078 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。