CAS NO: | 865783-99-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Briciclib (ON 014185) is a derivative of ON 013100, and has the potential in targetingeIF4Efor solid cancers. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 474.42 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C19H23O10PS | ||||||||||||||||
CAS 号 | 865783-99-9 | ||||||||||||||||
中文名称 | 布瑞西利 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 31 mg/mL(65.34 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |