CAS NO: | 314245-33-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | IU1 is a specialUsp14inhibitor with anIC50of 4-5 μM. | ||||||||||||||||
IC50& Target | IC50: 4-5 μM (Usp14)[1] | ||||||||||||||||
体外研究 (In Vitro) | Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro. IU1inhibits the catalytic activity of proteasome associated Usp14 in vitro. The IC50of IU1 for Usp14 is 4-5 μM. IU1 binds specifically to the activated form of Usp14. IU1 can potentially inhibit Usp14 by preventing its docking on the proteasome, but direct tests of this scenario proved negative. Usp14 inhibition is rapidly established upon addition of IU1 and rapidly reversed upon its removal. IU1 also promotes degradation of Sic1, a CDK inhibitor fromS. cerevisiae[1]. | ||||||||||||||||
分子量 | 300.37 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H21FN2O | ||||||||||||||||
CAS 号 | 314245-33-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 41.67 mg/mL(138.73 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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