TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesizedc-MPLagonist (CMA) andthrombopoietin (TPO) receptoragonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells^[1][2].

TA-316 (0.01-1000 nM; 4 days) stimulates UT-7/TPO and Ba/F3-HuMpl cells proliferation, with the EC₅₀values of 0.3 and 0.65 nM, respectively^[2].
TA-316 (800 nM; 10 days) promotes biased megakaryopoiesis and upregulated MK lineage markers^[2].
TA-316 (200 nM; 4 days) preferentially enhances VEGFA and FGF2 expression^[2].

641.56

Solid

C₂₈H₂₅BrN₄O₅S₂

1429321-13-0

Room temperature in continental US; may vary elsewhere.

DMSO : 50 mg/mL(77.94 mM;ultrasonic and warming and heat to 60℃)

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。