CAS NO: | 503468-95-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | KU-57788 (NU7441) is a highly potent and selectiveDNA-PKinhibitor with anIC50of 14 nM. KU-57788 is an NHEJ pathway inhibitor. KU-57788 also inhibitsPI3KandmTORwith IC50s of 5.0 and 1.7 μM, respectively[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | NU7441 (0.5 to 10 μM) inhibits the growth of liver cancer HepG2 cells dose- and time-dependently. NU7441 reduces pDNA-PKcs (S2056) protein expression in liver cancer cells. Furthermore, double treatment of NU7441 and 60Coγ IR affects DNA damage repair[2]. NU7441 is solvent-exposed in BRD4, this inhibitor can be classified as a Type I BRD inhibitor[4]. NU7441 reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[5]. | ||||||||||||||||
体内研究 (In Vivo) | KU-57788 (0.5 to 10 μM) inhibits the growth of liver cancer HepG2 cells dose- and time-dependently. KU-57788 reduces pDNA-PKcs (S2056) protein expression in liver cancer cells. Furthermore, double treatment of KU-57788 and 60Coγ IR affects DNA damage repair[2]. KU-57788 weakly inhibits BRD4 and BRDT with IC50s of 1 μM and 3.5 μM, respectively. KU-57788 is solvent-exposed in BRD4, this inhibitor can be classified as a Type I BRD inhibitor[4]. KU-57788 reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage[5]. | ||||||||||||||||
分子量 | 413.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H19NO3S | ||||||||||||||||
CAS 号 | 503468-95-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 14.29 mg/mL(34.56 mM;Need ultrasonic) 配制储备液
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