CAS NO: | 1919888-06-4 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | LY3295668 (AK-01) is a potent, orally active and highly specificAurora-A kinaseinhibitor, withKivalues of 0.8 nM and 1038 nM for AurA and AurB, respectively. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | LY3295668 is a highly specific Aurora-A kinase inhibitor, with Kivalues of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nm)[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 489.95 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H26ClF2N5O2 | ||||||||||||||||
CAS 号 | 1919888-06-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(204.10 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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