Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is afolic acidantagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibitsdihydrofolate reductase(DHFR)with aK_iof 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia^[1][2].

The IC₅₀value of Aminopterin (4-Aminofolic acid) against CCRF-CEM cells during 72 h of exposure is 4.4 nM^[2].
Aminopterin (4-Aminofolic acid) produces a marked inhibition of mitosis in low concentrations in human leukemic leukocytes^[4].

440.41

Solid

C₁₉H₂₀N₈O₅

54-62-6

氨基蝶呤

Room temperature in continental US; may vary elsewhere.

DMSO : 14.71 mg/mL(33.40 mM;Need ultrasonic)

H₂O : 5 mg/mL(11.35 mM;ultrasonic and adjust pH to 8 with NaOH)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。