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Folinic Acid Calcium Salt Pentahydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Folinic Acid Calcium Salt Pentahydrate图片
CAS NO:6035-45-6
包装与价格:
包装价格(元)
100mg电议
500mg电议
1 g电议
5 g电议

产品名称
Leucovorin calcium salt pentahydrate
产品介绍
Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) 是一种生物叶酸,通常与甲氨蝶呤 (MTX) 一起作为挽救剂服用,以降低 MTX 诱导的毒性。
生物活性

Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs)[1].

体内研究
(In Vivo)

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

Animal Model:24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2]
Dosage:7.0 mg/kg
Administration:Intraperitoneal injection; every second day; for 3 weeks
Result:Following methotrexate (MTX) administration appears to reverse this growth inhibition.
Clinical Trial
分子量

601.58

性状

Solid

Formula

C20H31CaN7O12

CAS 号

6035-45-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

溶解性数据
In Vitro: 

H2O : 10 mg/mL(16.62 mM;Need ultrasonic)

DMSO : 1 mg/mL(1.66 mM;ultrasonic and warming and heat to 80℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.6623 mL8.3114 mL16.6229 mL
5 mM0.3325 mL1.6623 mL3.3246 mL
10 mM0.1662 mL0.8311 mL1.6623 mL
*

请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用