MNK8

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MNK8

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2055078-49-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

MNK8 是一种有效的STAT3(信号换能器和转录激活器3) 抑制剂。MNK8 抑制 STAT3 的激活，降低其与 DNA 的结合能力。MNK8 对肝细胞癌 (HCC) 细胞具有良好的生长抑制作用。 MNK8 诱导肝癌细胞凋亡 (apoptosis)。 MNK8 降低 HCC 细胞的前生存蛋白表达和迁移/侵袭。

生物活性

MNK8 is a potentSTAT3(signal transducer and activator of transcription 3) inhibitor. MNK8 inhibitsSTAT3activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 inducesapoptosisin HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells^[1].

IC₅₀& Target

STAT3

Bcl-2

体外研究
(In Vitro)

MNK8 (50 μM, 0-48 h) increases Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1^[1].

分子量

252.27

Formula

C₁₅H₁₂N₂O₂

CAS 号

2055078-49-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.