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LQZ-7F
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LQZ-7F图片
CAS NO:354543-09-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LQZ-7F 是一种生存素二聚化 (survivin dimerization) 抑制剂,可在前列腺癌细胞中诱导自发细胞凋亡 (apoptosis) 并与多西紫杉醇协同作用。LQZ-7F 剂量依赖性地抑制 PC-3 和 C4-2 细胞的存活,IC50分别为 2.99 和 2.47 μM。
生物活性

LQZ-7F, asurvivindimerizationinhibitor, induces spontaneousapoptosisand synergizes with Docetaxel in prostatecancercells. LQZ-7F dose-dependently inhibits survival of both PC-3 and C4-2 cells with IC50s of 2.99 and 2.47 μM, respectively[1].

体外研究
(In Vitro)

LQZ-7F could be hudrolyzed under acidic conditions[1].
LQZ-7F (2.5 μM, 72 hours) displays cytotoxicity towards human cancer cells (PC-3, C4-2) with the IC50s of 2.99 μM and 2.74 μM, respectively[1].
LQZ-7F effectively inhibits survival of all cancer cell lines with IC50values ranging between 0.4 and 4.4 mM[2].
LQZ-7F (2 μM, 24 hours) disrupts microtubule structure and cause mitotic arrest in P3 cells[2].

Apoptosis Analysis[1]

Cell Line:PC3, HL-60 cells
Concentration:0, 5, 10 μM
Incubation Time:
Result:Caused 54% to 69% apoptosis for PC3 and 66% to 98% apoptosis for HL-60 cells.

Cell Cytotoxicity Assay[1]

Cell Line:PC-3, DU145
Concentration:10, 20 μM
Incubation Time:72 hours
Result:Showed that the IC50in human PC3 and DU145 cells was approximately 25 μM.
体内研究
(In Vivo)

LQZ-7F (i.p. injection; 25 mg/kg once every 3 days; 24 days) inhibits growth of xenograft tumor and may be due to its induction of surviving degradation in vivo[1].

Animal Model:4- to 6-week-old male NSG (NOD/SCID/IL-2Rg null) mice[2].
Dosage:25 mg/kg
Administration:24 days
Result:Inhibited growth of xenograft tumors by inhibiting surviving.
分子量

349.26

Formula

C14H7N9O3

CAS 号

354543-09-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.