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Kongensin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kongensin A图片
CAS NO:885315-96-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Kongensin A 是一种从Croton kongensis中分离的天然产物。 Kongensin A 是一种有效的,共价的HSP90抑制剂,可阻断RIP3依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂,并具有潜在的抗坏死性和消炎性应用。
生物活性

Kongensin A is a natural product isolated fromCroton kongensis. Kongensin A is an effective, covalentHSP90inhibitor that blocksRIP3-dependent necroptosishas. Kongensin A is a potentnecroptosisinhibitor and anapoptosisinducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications[1].

IC50& Target

HSP90[1]
RIP3[1]
Apoptosis[1]

体外研究
(In Vitro)

Kongensin A (0-15 μM; 6 hours; HT29 cells) treatment induces caspase activation and apoptosis in multiple cancer cell lines in a dosage-dependent manner[1].
Kongensin A (0-15 μM; 24 hours; HT29 cells) treatment induces the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induces the up-regulation of HSP90A and HSP90B[1].
Kongensin A covalently binds to cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37. The HSP90-CDC37 complex is required for RIP3 activation, KA blocks LPS/Smac mimetics/Z-VAD and RIP3 polymerization-induced cell death, in which cell death is dependent on RIP3 but not its upstream kinase RIP1[1].

Apoptosis Analysis[1]

Cell Line:HT29 cells
Concentration:0 μM, 2.5 μM, 5 μM, 15 μM
Incubation Time:6 hours
Result:Induced caspase activation and apoptosis in a dosage-dependent manner.

Western Blot Analysis[1]

Cell Line:HT29 cells
Concentration:0 μM, 2.5 μM, 5 μM, 15 μM
Incubation Time:24 hours
Result:Induced the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induced the up-regulation of HSP90A and HSP90B.
分子量

374.47

性状

Solid

Formula

C22H30O5

CAS 号

885315-96-8

来源
  • Plants
  • Euphorbiaceae
  • Croton kongensisGagnep.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)