CAS NO: | 1071992-57-8 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor ofapoptosisproteins(IAPs). Xevinapant hydrochloride binds toXIAP,cIAP1, and cIAP2 proteins withKis of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizesXIAPBIR3 protein in a cell-free functional assay, induces rapid degradation of cellularcIAP1protein, and inhibitscancercell growth in various humancancercell lines. Xevinapant hydrochloride is highly effective in induction ofapoptosisin xenograft tumors[1][2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Xevinapant (AT-406) hydrochloride potently inhibits cell growth in the MDA-MB-231 breast and SK-OV-3 ovarian cancer cell lines with IC50=144 nM and 142 nM, respectively. Xevinapant (0-3 μM; 0-48 horus) hydrochloride effectively induces cell death in a time- and dose-dependent manner[1]. | ||||||||||||||||
体内研究 (In Vivo) | Xevinapant (AT-406) hydrochloride is very effective in inhibition of tumor growth in the MDA-MB-231 xenograft model, and has minimal toxicity to animals[1].
Xevinapant hydrochloride evaluated for its pharmacokinetic (PK) properties in mice, rats, non-human primates and dogs[1].
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Clinical Trial | |||||||||||||||||
分子量 | 598.18 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C32H44ClN5O4 | ||||||||||||||||
CAS 号 | 1071992-57-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 175 mg/mL(292.55 mM;Need ultrasonic) 配制储备液
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