HS38

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HS38

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1030203-81-6

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

HS38 是一种高效、选择性的，ATP 竞争性的DAPK1和ZIPK (DAPK3)抑制剂，K_d值分别为 300 nM 和 280 nM。HS38 也是PIM3的抑制剂，其IC₅₀值为 200 nM。HS38 可用于平滑肌相关疾病的研究。

生物活性

HS38 is a potent, selective, and ATP-competitive inhibitor ofdeath-associated protein kinase 1 (DAPK1)andzipper-interacting protein kinase (ZIPK, also called DAPK3), withK_ds of 300 nM and 280 nM, respectively. HS38 is also aPIM3inhibitor with anIC₅₀of 200 nM. HS38 can be used for the research of smooth muscle related disorders^[1].

IC₅₀& Target

Kd: 300 nM (DAPK1), 79 nM (DAPK2), 280 nM (ZIPK), IC50: 200 nM (DAPK1), 200 nM (PIM3)^[1]

体外研究
(In Vitro)

HS38 displays high affinity toward DAPK2, with a K_dof 79 nM. DAPK2 is not implicated in smooth muscle contractility^[1].
HS38 significantly reduces relative RLC20 phosphorylation in both the basal and sphingosine 1-phosphate (S1P) activated states in human aortic SM cells^[1].
HS38 reduces contractile forces generated by intact mouse aorta in aortic tissue^[1].
HS38 reduces the contractile force, RLC20 phosphorylation, and MYPT1 phosphorylation in Ca²⁺-sensitized rabbit ileum^[1].

Western Blot Analysis^[1]

Cell Line:	CA-VSMCs
Concentration:	10 μM
Incubation Time:	40 minutes
Result:	Reduced relative RLC20 phosphorylation in both the basal and S1P activated states.

分子量

349.80

性状

Solid

Formula

C₁₄H₁₂ClN₅O₂S

CAS 号

1030203-81-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 7.14 mg/mL(20.41 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.8588 mL	14.2939 mL	28.5878 mL
5 mM	0.5718 mL	2.8588 mL	5.7176 mL
10 mM	0.2859 mL	1.4294 mL	2.8588 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。