Belantamab mafodotin

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2050232-20-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

GSK2857916
Belantamab mafodotin-blm

产品介绍

Belantamab mafodotin (GSK2857916) 是由人源化、聚焦化的抗 B 细胞成熟抗原 (BCMA) 单克隆抗体和 McMMAF 组成，具有抗骨髓瘤活性。

生物活性

Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody againstB cell maturation antigen (BCMA)andMcMMAF. Belantamab mafodotin has anti-myeloma activity^[1]^[2].

体外研究
(In Vitro)

Belantamab mafodotin binds to human BCMA protein with a K_dof 1 nM^[2].
Belantamab mafodotin induces G2/M arrest in multiple myeloma cells in a dose and time dependent manner^[2].
Belantamab mafodotin signifcantly promotes phagocytosis of multiple myeloma cells by human macrophages derived from macrophage colony-stimulating factor-stimulated monocytes^[2].

体内研究
(In Vivo)

Belantamab mafodotin signifcantly improves survival compared to vehicle in mice harbouring OPM2 tumours^[2].

Animal Model:	Mice harbouring OPM2 tumours^[2]
Dosage:	4 mg/kg
Administration:	IP, twice weekly for 4 doses
Result:	Signifcantly improves survival compared to vehicle.

CAS 号

2050232-20-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.