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Trientine(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trientine(hydrochloride)图片
CAS NO:38260-01-4
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议

产品介绍
Cas No.38260-01-4
别名盐酸三乙烯四胺,Triethylenetetramine
化学名N1,N2-bis(2-aminoethyl)-1,2-ethanediamine, dihydrochloride
Canonical SMILESNCCNCCNCCN.Cl.Cl
分子式C6H18N4•2HCl
分子量219.2
溶解度Slightly soluble in Water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Trientine is a polyamine chelating agent.[1] It reduces the amount of a copper-albumin complex and increases formation of low molecular weight complexes in a dialysis assay in a concentration-dependent manner. Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. In vivo, trientine (40 mg/kg, i.v.) mobilizes copper in the kidneys, but not the liver, to increase urinary excretion in rats. Trientine also decreases nickel accumulation in the liver, kidney, and spleen in mice injected with nickel chloride. [2] Formulations containing trientine have been used to reduce copper accumulation in patients with Wilson’s disease.

Reference:
[1]. Sarkar, B., Sass-Kortsak, A., Clarke, R., et al. A comparative study of in vitro and in vivo interaction of D-penicillamine and triethylenetetramine with copper. Proc. R. Soc. Med. 70(Suppl 3), 13-18 (1977).
[2]. Behari, J.R. Use of liposome entrapped triethylenetetramine (TETA) in the treatment of mice loaded with nickel chloride. Ind. Health 25(4), 221-224 (1987).