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Withanolide B
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Withanolide B图片
CAS NO:56973-41-2
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Withanolide B 是 W 的活性成分。
Cas No.56973-41-2
别名睡茄素B
Canonical SMILESO=C1[C@@]2(C)[C@]([C@@H](O3)[C@@H]3[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@@H]5[C@H](C)[C@@]6(OC(C(C)=C(C)C6)=O)[H])(O)CC=C1
分子式C28H38O5
分子量454.6
溶解度Acetonitrile: 0.1 mg/ml,Methanol: 0.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does not increase glucose uptake in L6 myotubes. In in silico docking studies, withanolide B was identified as a neuronal nitric oxide synthase (nNOS) inhibitor (Ki = 5.15 nM), that also inhibited inducible NOS (iNOS) and endothelial NOS (eNOS; Kis = 15.48 and 66.59 nM, respectively), and as a ligand for the PARP1 catalytic domain with an estimated Ki value of 7.54 nM.