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ZK118182 isopropyl ester
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ZK118182 isopropyl ester图片
CAS NO:154927-31-8
包装与价格：
包装价格(元)
100μg电议
500μg电议

产品介绍
Cas No.154927-31-8
Canonical SMILESCl[C@H]1[C@H](C/C=C\COCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)C2CCCCC2)[C@H](O)C1
分子式C23H37ClO5
分子量429
溶解度DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: 12.5 mg/ml,Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.