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2-Deoxy-D-glucose
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2-Deoxy-D-glucose图片
CAS NO:154-17-6
包装与价格:
包装价格(元)
500mg电议
1 g电议
5 g电议
10 g电议
50 g电议

产品名称
2-脱氧-D-葡萄糖
2-DG
2-Deoxy-D-arabino-hexose
D-Arabino-2-deoxyhexose
产品介绍
2-Deoxy-D-glucose 是一种葡萄糖类似物,为葡萄糖代谢抑制剂,通过作用于己糖激酶 (hexokinase) 来抑制糖酵解 (glycolysis)。
生物活性

2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibitingglycolysisvia its actions onhexokinase[1].

IC50& Target[1]

HSV-1

 

体外研究
(In Vitro)

2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner that paralleles the effects of 2-DG on cell growth. The levels of phosphorylated Akt are significantly decreased, whereas the levels of phosphorylated AMPK and Sirt-1 are significantly increased in MCF-7 cells exposed to 2-Deoxy-D-glucose at 4, 8, or 16 mM for 1, 3, or 5 days in a dose- and time-dependent manner[1]. 2-DG treatment increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase. An increase in NADPH and upregulation of glutathione synthetase expression resultes in the increase in the reduced form of glutathione by 2-DG in NB4 cells[3].

体内研究
(In Vivo)

2-Deoxy-D-glucose (0.03%, w/w) causes a 7% decrease in final weight that is statistically significant, and delayes the appearance of palpable mammary carcinomas[1]. 2-Deoxy-D-glucose (3 mmol/kg, i.v.) is decreased in a dose-dependent manner in rat muscle[2].

Clinical Trial
分子量

164.16

性状

Solid

Formula

C6H12O5

CAS 号

154-17-6

中文名称

2-脱氧-D-葡萄糖

结构分类
  • Saccharides
  • Monosaccharides
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : ≥ 24 mg/mL(146.20 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM6.0916 mL30.4581 mL60.9162 mL
5 mM1.2183 mL6.0916 mL12.1832 mL
10 mM0.6092 mL3.0458 mL6.0916 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 130 mg/mL (791.91 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。