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DPC-681
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DPC-681图片
CAS NO:284661-68-3
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品名称
DPH-153893
产品介绍
DPC-681是一种有效的选择性HIV protease 抑制剂, 抑制野生型HIV-1IC90 值为4 - 40 nM。
生物活性

DPC-681 is a potent and selective inhibitor ofHIV proteasewith IC90s for wild-typeHIV-1of 4 to 40 nM. IC50 value: 4 - 40 nM [1] Target:HIV proteasein vitro: DPC 681 is extremely potent inhibitor of wild-typeHIV-1. When all of theHIV-1strains tested are considered, the average concentrations required for 90% inhibition of replication were 7.3 ± 3.4 for DPC 681. DPC 681 shows no loss in potency toward recombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions. [1] in vivo: The total body clearance (CL) of DPC 681 in dogs was high (1.8 liter/h/kg) equaling hepatic blood flow for this species (1.8 liter/h/kg). After an oral dosing, the Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively). These data suggest that hepatic extraction (first-pass effect) can be saturated in the dog. [1]

IC50& Target

HIV-1

 

分子量

669.85

性状

Solid

Formula

C35H48FN5O5S

CAS 号

284661-68-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL(149.29 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.4929 mL7.4644 mL14.9287 mL
5 mM0.2986 mL1.4929 mL2.9857 mL
10 mM0.1493 mL0.7464 mL1.4929 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。