Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable prodrug of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibitsNS5B polymerase, causing chain termination^[1][2].

HCV^[1]

Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) shows the C_max, AUC, t_1/2, and t_maxwere 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively^[2].

356.37

C₁₅H₂₄N₄O₆

640281-90-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.