CAS NO: | 1355050-21-3 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viralRNA-dependent RNA-polymerases (RdRp)inhibitor withIC50s of 1.1 μM, 5 μM forRSVRdRp andHCVRdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2]. | ||||||||||||||||
IC50& Target | IC50: 1.1 μM (RSV RdRp) and 5 μM (HCV RdRp)[1][2] | ||||||||||||||||
体外研究 (In Vitro) | In a continuous 72 h incubation of 1 μM Remdesivir (GS-5734), the GS-443902 trisodium (GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium) level is measured at 2, 24, 48 and 72 h, and reaches a Cmaxof 300, 110, and 90 pmol/million cells in macrophages, HMVEC, and HeLa cells lines respectively[1]. | ||||||||||||||||
体内研究 (In Vivo) | Remdesivir (GS-5734; 10 mg kg; i.v.) rapidly distributes into peripheral blood mononuclear cells (PBMCs), and efficient conversion to GS-443902 trisodium (Remdesivir metabolite trisodium; NTP) is apparent within 2 h of dose administration in rhesus monkeys. In PBMCs, GS-443902 trisodium represents the predominant metabolite and is persistent with a t1/2of 14 h and levels required for >50% virus inhibition for 24 hours[3]. | ||||||||||||||||
分子量 | 597.15 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C12H13N5Na3O13P3 | ||||||||||||||||
CAS 号 | 1355050-21-3 | ||||||||||||||||
中文名称 | 瑞德西韦代谢物三钠盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -80°C, protect from light, stored under nitrogen *该产品在溶液状态不稳定,建议您现用现配,即刻使用。 | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 33.33 mg/mL(55.82 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |