CAS NO: | 209216-23-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor ofHBV, with anEC50of 3.75 nM in HepG2 cell. | ||||||||||||||||
IC50& Target | EC50:3.75 nM (anti-HBV, HepG2 cell)[1] | ||||||||||||||||
体外研究 (In Vitro) | Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) has a EC50of 3.75 nM against HBV. It is incorporated into the protein primer of HBV and subsequently inhibits the priming step of the reverse transcriptase. The antiviral activity of BMS-200475 is significantly less against the other RNA and DNA viruses[1]. | ||||||||||||||||
体内研究 (In Vivo) | Daily oral treatment with Entecavir monohydrate at doses ranging from 0.02 to 0.5 mg/kg of body weight for 1 to 3 months effectively reduces the level of woodchuck hepatitis virus (WHV) viremia in chronically infected woodchucks[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 295.29 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C12H17N5O4 | ||||||||||||||||
CAS 号 | 209216-23-9 | ||||||||||||||||
中文名称 | 恩替卡韦 (1水合物) | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 50 mg/mL(169.33 mM) H2O : 2.8 mg/mL(9.48 mM;Need ultrasonic and warming) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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