Oxychloroaphine could be isolated from the bacteriumPantoeaagglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and inducesapoptosis. Oxychloroaphine can be used in research ofcancer^[1][2].

Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC₅₀values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM^[2].
Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein^[2].
Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase^[2].
Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP^[2].

223.23

Solid

C₁₃H₉N₃O

550-89-0

• Others

Phytopathogenic bacteria

Room temperature in continental US; may vary elsewhere.