CAS NO: | 160369-77-7 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Fomivirsen (ISIS-2922) sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen sodium is anantiviral agentthat is usedcytomegalovirus retinitis (CMV)research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encodingCMVimmediate-early 2 protein, thus inhibiting virus proliferation[1][2]. | ||||||||||||||||
体外研究 (In Vitro) | Antisense oligonucleotide acts a complementary nucleotide to the messenger RNA of the major immediate-early region proteins of human cytomegalovirus, it disrupts the replication of the virus through an antisense mechanism[1].Fomivirsen is 21-mer phosphorothioate ASO with CpG motif near its 5′ end, with the sequence 5′-GCG TTT GCT CTT CTT CTT GCG-3′, resulting in mRNA degradation by RNase H-mediated mechanism[2].Fomivirsen inhibits CMV replication in human retinal pigment epithelial (RPE) cells and in human fibroblast cells (MRC-5 cells) in a dose-dependent manner. The mean IC50are 0.03 μM for RPE cells and 0.2 μM for MRC5 cells[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 7122.09 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
CAS 号 | 160369-77-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 100 mg/mL(14.04 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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