CAS NO: | 50-91-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibitsPoly(ADP-Ribose) polymeraseand induces DNA damage by activating theATMandATRcheckpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor forS. aureusinfectionand induces cellapoptosis[1][2]. Floxuridine has antiviral effects againstHSVandCMV[3]. | ||||||||||||||||||||||||
IC50& Target[1][2][3] |
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体外研究 (In Vitro) | Floxuridine (0-25 μM; 4-24 hours) is affectd by inhibitors of PARP and its sensitivity of ovarian cancer cells is enhanced. Co-exposed to FdUrd and the PARP inhibitor markedly increases killing cell numbers when its compare to treatment alone in ovarian cancer cells[1].Floxuridine (300 μM; 4-24 hours) increases p-Chk1 and p-Chk2 in ovarian cancer cell lines. It may induce DNA damage and activate the ATM and ATR checkpoint signaling pathways[1].Floxuridine (0-2.5 μM; 24 hours) causes a G1/S-phase arrest and following removal of the FdUrd, the G1/S-phase-arrested cells moved synchronously through S phase and into G2/M[1].Floxuridine is againstMueller Hinton BrothandTryptic Soy Brothwith MIC values of 0.25 μM and 0.81 μM, respectively. It also reported to be a very potent inhibitor ofstaphylococcalgrowth (MIC, 0.025–0.00313 μM)[2]. Cell Viability Assay[1]
Western Blot Analysis[1]
Cell Cycle Analysis[1]
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体内研究 (In Vivo) | Floxuridine (intraperitoneal injection; 0.5-1.25 mg/kg; once per day for 7 days or single dose) is sufficient to show statistically significant protection against S. aureus infection at 0.5 mg/kg for 7 days. In addition, 1.25 mg/kg single administration of the compound shows statistically significant protection against S. aureus infection[2].
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Clinical Trial | |||||||||||||||||||||||||
分子量 | 246.19 | ||||||||||||||||||||||||
性状 | Solid | ||||||||||||||||||||||||
Formula | C9H11FN2O5 | ||||||||||||||||||||||||
CAS 号 | 50-91-9 | ||||||||||||||||||||||||
中文名称 | 氟尿苷;氟脲脱氧核苷;氟苷;5-氟去氧尿苷 | ||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(507.74 mM;Need ultrasonic) H2O : ≥ 50 mg/mL(203.10 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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