CAS NO: | 489416-12-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | ST-193 is a potent broad-spectrumarenavirusinhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus withIC50values of 0.44, 0.62, 1.4 and 3.1 nM, respectively. | ||||||||||||||||
IC50& Target | IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)[1] | ||||||||||||||||
体外研究 (In Vitro) | ST-193 inhibits LASV pseudotypes with an IC50of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC50s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM[2]. | ||||||||||||||||
体内研究 (In Vivo) | ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups[3]. | ||||||||||||||||
分子量 | 371.47 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H25N3O | ||||||||||||||||
CAS 号 | 489416-12-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(269.20 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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