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Belapectin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1980787-47-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
GR-MD-02
产品介绍
Belapectin (GR-MD-02) 是一种半乳凝素-3 (Gal-3) 抑制剂。Belapectin 通过诱导 T 细胞凋亡 (Apoptosis) 来驱动肿瘤诱导的免疫抑制。Belapectin 通过 CD8+ T 细胞依赖机制,促进肿瘤消退并提高荷瘤小鼠生存率。Belapectin 结合Gal-3的 Ki为 2.8 μM。
生物活性

Belapectin (GR-MD-02) is aGalectin-3 (Gal-3)inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cellApoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Kiof 2.8 μM[1][2].

IC50& Target

Ki: 2.8 μM (Galectin-3)[2]

体外研究
(In Vitro)

Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) 抑制 4T1 和 MCA-205 细胞的增殖,诱导凋亡[1]

Apoptosis Analysis[1]

Cell Line:TRAMP-C1, 4T1 and MCA-205 cells
Concentration:0.2 mg/mL, 2 mg/mL
Incubation Time:48 h
Result:Decreased the proliferation and resulted a minimal increase in apoptosis of 4T1 and MCA-205 cells. But showed no impact on TRAMP-C1 cell.
体内研究
(In Vivo)

Belapectin (2.4 mg/mouse; 腹腔注射; 每周 3 次, 共 3 周) 仅与 anti-OX40 mAb 联合处理后,才导致肿瘤生长显著减少、存活率相应增加。联合处理还产生了持久的长期记忆,100% 无瘤小鼠被保护免于随后的肿瘤再攻击[1]

Animal Model:Wild-type C57BL/6 and BALB/c mice[1]
Dosage:2.4 mg/mouse, accompanied with anti-OX40 mAb (250 μg)
Administration:Intraperitoneal injection; 3 times per week for 3 weeks
Result:Inhibited tumor growth.
Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy.
CAS 号

1980787-47-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.