CAS NO: | 1980787-47-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Belapectin (GR-MD-02) is aGalectin-3 (Gal-3)inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cellApoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Kiof 2.8 μM[1][2]. | ||||||||
IC50& Target | Ki: 2.8 μM (Galectin-3)[2] | ||||||||
体外研究 (In Vitro) | Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) 抑制 4T1 和 MCA-205 细胞的增殖,诱导凋亡[1]。 Apoptosis Analysis[1]
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体内研究 (In Vivo) | Belapectin (2.4 mg/mouse; 腹腔注射; 每周 3 次, 共 3 周) 仅与 anti-OX40 mAb 联合处理后,才导致肿瘤生长显著减少、存活率相应增加。联合处理还产生了持久的长期记忆,100% 无瘤小鼠被保护免于随后的肿瘤再攻击[1]。
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CAS 号 | 1980787-47-0 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |