| CAS NO: | 210825-31-3 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 210825-31-3 |
| Canonical SMILES | O=S(C1=CC(C(O)(C)C)=CC=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O |
| 分子式 | C22H29ClN2O4S |
| 分子量 | 452.99 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Inhibitor of IL-1β post-translational processing (IC50 = 210 nM). Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable. Perregaux et al (2001) Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J.Pharmacol.Exp.Ther. 299 187 PMID:11561079 |Baldwin et al (2016) Inhibiting the inflammasome: a chemical perspective. J.Med.Chem. 59 1691 PMID:26422006 |
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