化学性质
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 434.71 |
| Cas No. | 17374-26-4 |
| Formula | C6HBr4N3 |
| Synonyms | NSC 231634; TBB (enzyme inhibitor);1H-Benzotriazole, 4,5,6,7-tetrabromo- |
| Solubility | insoluble in H2O; ≥159.2 mg/mL in DMSO; ≥10.42 mg/mL in EtOH with ultrasonic |
| Chemical Name | 4,5,6,7-tetrabromo-2H-benzotriazole |
| Canonical SMILES | C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). TBB exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. TBB acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. The effect of TBB on PC-3 human prostate cancer cell viability depends on the time schedule of administration.
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