WAY-204688(SIM-688)

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WAY-204688(SIM-688)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	796854-35-8
规格:	≥98%

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议
100mg	电议
250mg	电议

产品介绍

WAY-204688 (WAY204688; WAY 204688; SIM688; SIM-688) is a novel, potent, selective and orally bioactive agonist of estrogen receptor (ER-α) and also an inhibitor of NF-κB transcriptional activity with anti-inflammatory effects. It inhibits NF-κB-luciferase (NF-κB-luc) with an IC50 of 122 ± 30 nM in HAECT-1 cells. WAY-204688 has the potential to be used for the treatment of rheumatoid arthritis.

理化性质和储存条件

	Molecular Formula: C34H31F3N2O2 Exact Mass: 556.2338 Molecular Weight: 556.6292
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Technical Information	Synonym: SIM-688; WAY-204688; SIM 688; WAY204688; SIM688; WAY 204688 Chemical Name: (2S,3S)-3-(2-methoxyphenyl)-2-methyl-3-(naphthalen-1-yl)-2-(4-(3-(trifluoromethyl)phenyl)piperidine-1-carbonyl)propanenitrile InChi Key: JZPONCMNBSEYQW-MOJIJOCKSA-N InChi Code: InChI=1S/C34H31F3N2O2/c1-33(22-38,32(40)39-19-17-23(18-20-39)25-11-7-12-26(21-25)34(35,36)37)31(29-14-5-6-16-30(29)41-2)28-15-8-10-24-9-3-4-13-27(24)28/h3-16,21,23,31H,17-20H2,1-2H3/t31-,33?/m0/s1 SMILES: COC1=C(C=CC=C1)[C@H](C2=CC=CC3=CC=CC=C32)[C@](C(N4CCC(C5=CC=CC(C(F)(F)F)=C5)CC4)=O)(C#N)C