| CAS NO: | 38647-11-9 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 10mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 358.39 |
| Cas No. | 38647-11-9 |
| Formula | C20H22O6 |
| Synonyms | NSC 165677; PG 492 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥16.35 mg/mL in DMSO |
| Chemical Name | (5bS,6aS,7aS,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-1,5b,6,6a,8a,9a,9b,10b-otahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3,8(2H,5H)-dione |
| Canonical SMILES | CC([C@]12[C@@H](O2)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@]5([H])C[C@H]7[C@@]4(O7)C1=O)COC6=O)C)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Cell experiment:[1] | |
Cell lines | Human B-lymphoma Raji and T-lymphoma Jurkat cell lines |
Reaction Conditions | 0 ~ 80 nM for 3 or 6 days |
Applications | These two lymphoma cell lines were very sensitive to triptonide in a dose-dependent manner, with the IC50 of 11.4 nM at 3 days and 5.7 nM at 6 days in B-lymphoma Raji cells, and 11.1 nM at 3 days and 4.8 nM at 6 days in T-lymphoma Jurkat cells, respectively. |
| Animal experiment:[1] | |
Animal models | Eight-week-old female NOD/SCID mice (18 ~ 22 g) xenografted with Raji cells |
Dosage form | 5 mg/kg Once daily by intraperitoneal injection for 34 days |
Applications | Triptonide at a dose of 5 mg/kg/day almost completely inhibited the lymphoma growth in human lymphoma cells-xenografted mice without obvious side effects. Moreover, the tumors in 6 mice among the 8 xenografted mice were completely eradicatedin vivo. |
Note | The technical data provided above is for reference only. |
References: 1. Yang P, Dong F, Zhou Q. Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway. Toxicology Letters, 2017, 278: 9-17. | |
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