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Heparin sodium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO:9041-08-1
包装与价格：
包装价格(元)
100mg电议
500mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt6000-20000
Cas No.9041-08-1
Solubilityinsoluble in EtOH; insoluble in DMSO; ≥12.75 mg/mL in H2O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Minimum activity: >150 I.U./mg. Glycosaminoglycan that behaves as an anticoagulant. Binds with high affinity to antithrombin III (AT-III).

试验操作

Animal experiment:[1]

Animal models

Male New Zealand rabbits with a mean body weight of 2300 ± 300 g

Dosage form

2000 IU heparin

Administered by the intravenous route (i.v.)

Applications

Heparin increased both anti-factor Xa activity and activated partial thromboplastin time (aPTT). Heparin (2000 IU, i.v.) showed an AUC0→24/kg value of 3.30 ± 0.59 IU·h-1·mL-1·kg-1, with 100% absolute bioavailability. Apart from the parenteral route, heparin could also be administered by the oral route when incorporated into polymeric nanoparticles which were able to maintain the anti-Xa activity of heparin for a longer period.

Note

The technical data provided above is for reference only.

References:

1. Jiao Y, Ubrich N, Marchand-Arvier M, et al. In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation, 2002, 105(2): 230-235.