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MCH-1 antagonist 1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MCH-1 antagonist 1图片
CAS NO:1039825-68-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
MCH-1antagonist1是一种有效的黑色素浓缩激素1(MCH-1)拮抗剂，Ki值为2.6nM。MCH-1antagonist1还抑制CYP3A4，IC50为10μM。
Cas No.1039825-68-7
Canonical SMILESO=C1C=C(OCC2=CC=CC=C2)C=CN1C3=CC4=C(N(CCN5CCCC5)N=C4)C=C3
分子式C25H26N4O2
分子量414.5
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM.

MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM[1].

MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL[1].

[1]. Henderson AJ, et al. Tetrahydrocarboline analogs as MCH-1 antagonists. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7024-8.