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Tarazepide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tarazepide图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Tarazepide是一种有效且特异性的CCK-A受体拮抗剂。

Animal experiment:

Calve[1] The 5 to 7-day-old Friesian male calves (42.0±1.5 kg body weight) are used. The study is made on four calves. After recording 2 to 3 preprandial (interdigestive) MMC/PPS cycles, Tarazepide suspension (0.05, 0.5 and 5.0 mg/kg body weight), or vehicle alone (1% methylcellulose) is infused intraduodenally (i.d.).

产品描述

Tarazepide is a potent and specific CCK-A receptor antagonist.

Tarazepide decreases duodenal electric activity, reduces interdigestive pancreatic secretion, especially protein; reduces cephalic and early postprandial (milk) induced secretion of bicarbonate and protein.Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±Atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine[1]. Leptin is administered to the animals at doses of 0.1, 1.0 or 10.0 μg/kg i.d. Tarazepide (2.5 mg/kg, i.d.), a CCK(1) receptor antagonist, is given to the rats prior to the application of leptin. CCK plasma level is measured by radioimmunoassay (RIA) following administration of leptin to the rats. Intraduodenal administration of leptin (1.0 or 10.0 microg/kg) to the fasted rats significantly and dose-dependently increases pancreatic protein and amylase outputs. Pancreatic secretory responses to leptin were totally abolished by prior capsaicin deactivation of sensory nerves or by pretreatment of the rats with Tarazepide[2].

[1]. Zabielski R, et al. Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. Regul Pept. 1998 Nov 30;78(1-3):113-23. [2]. Nawrot-Porabka K, et al. Leptin is able to stimulate pancreatic enzyme secretion via activation of duodeno-pancreatic reflex and CCK release. J Physiol Pharmacol. 2004 Jul;55 Suppl 2:47-57.