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ML-109
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ML-109图片
CAS NO:1186649-91-1
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
ML-109是有效的、促甲状腺激素受体(TSHR)的全激动剂，其EC50值为40nM。
Cas No.1186649-91-1
Canonical SMILESCC(NC1=CC=C(OCC2=CC(C(N3CC4=CC=CC=C4)NC5=C(C(O)=CC=C5)C3=O)=CC=C2OC)C=C1)=O
分子式C31H29N3O5
分子量523.58
溶解度DMSO: 83.33 mg/mL (159.15 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.

ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h)[1].

[1]. Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6.