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MreB Perturbing Compound A22
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MreB Perturbing Compound A22图片
CAS NO:22816-60-0
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
MreB 扰动化合物 A22 是一种苄基异硫脲化合物,可与 MreB 的 ATP 结合位点快速且可逆地相互作用。
Cas No.22816-60-0
别名A22 hydrochloride
Canonical SMILESClC1=CC(CSC(N)=N)=CC=C1Cl.Cl
分子式C8H8Cl2N2S•HCl
分子量271.6
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MreB is an actin-like protein expressed in bacteria. It determines the rod shape of cells and has critical roles in cell division, chromosome segregation, and cell polarity. MreB perturbing compound A22 is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly. It blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml). It interferes with chromosome segregation in C. crescentus by preventing MreB binding to chromosomes. In V. cholerae, A22 prevents the development of normal cell shape and alters nucleoid morphology.