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Teriflunomide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Teriflunomide图片
CAS NO:108605-62-5
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
100mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt270.21
Cas No.108605-62-5
FormulaC12H9F3N2O2
Solubilityinsoluble in H2O; ≥13.5 mg/mL in DMSO; ≥2.54 mg/mL in EtOH with gentle warming and ultrasonic
Chemical Name(Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
Canonical SMILESCC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Teriflunomide (also known as A77 1726), the active metabolite of an approved antirheumatic drug Leflunomide, is an emerging oral therapy for multiple sclerosis (MS). Teriflunomide has demonstrated anti-inflammatory, antiproliferative and immunosuppressive

试验操作

Cell experiment:[1]

Cell lines

Human synoviocytes

Reaction Conditions

10-7~ 10-4M teriflunomide for 50 h incubation

Applications

Teriflunomide inhibited the production of prostaglandin E2in TNF-α- or IL-1α-stimulated isolated human synoviocytes (IC50s = 7 and 3 μM, respectively). At higher concentrations (>10 μM), teriflunomide also reduced the production of matrix metalloproteinase 1 and IL-6 due to the known inhibitory effect of teriflunomide on pyrimidine synthesis, which could be reversed by the addition of uridine.

Animal experiment:[2]

Animal models

Male Dark Agouti (DA) rat, 6-week old

Dosage form

3 and 10 mg/kg

Once daily by oral route

Applications

Teriflunomide (3 and 10 mg/kg) delayed disease onset and decreased neurological deficits in a rat model of experimental autoimmune encephalomyelitis induced by complete Freund’s adjuvant andMycobacterium tuberculosis.

Note

The technical data provided above is for reference only.

References:

1. Burger D, Begué-Pastor N, Benavent S, et al. The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes. Rheumatology (Oxford), 2003, 42(1): 89-96.

2. McMonagle-Strucko K. Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. Journal of Neurology, 2009, 256(1): 89-103.