| CAS NO: | 717824-30-1 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 355.36 |
| Cas No. | 717824-30-1 |
| Formula | C20H18FNO4 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥103 mg/mL in DMSO |
| Chemical Name | 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid |
| Canonical SMILES | FC1=CC(C2=CC=CC(OC)=C2)=CC=C1NC(C3=C(C(O)=O)CCC3)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Vidofludimus (4SC-101, SC12267) 是一种新型的二氢乳清酸脱氢酶(DHODH)小分子抑制剂,对人类DHODH的IC50值为134 nmol/L [1].
在体外酶实验中,Vidofludimus (4SC-101, SC12267)以剂量依赖的方式抑制DHODH,对人类DHODH\大鼠DHODH\小鼠DHODH和人类PBMC的IC50值分别为0.134 μmol/L, 1.29 μmol/L, 10.6 μmol/L和12.9 μmol/L[1].Vidofludimus对植物血凝素诱导的淋巴细胞增殖有抑制作用,IC50值约为13 μmol/L.Vidofludimus浓度依赖性地抑制植物血凝素刺激的人外周血单核细胞系(PBMCs)分泌白细胞介素-17,IC50值为6 μmol/L [2].
参考文献：
[1] Kulkarni OP1, Sayyed SG, Kantner C, Ryu M, Schnurr M, Sárdy M, Leban J, Jankowsky R, Ammendola A, Doblhofer R, Anders HJ. 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas) lpr mice. Am J Pathol. 2010 Jun;176(6):2840-7.
[2] Fitzpatrick LR1, Deml L, Hofmann C, Small JS, Groeppel M, Hamm S, Lemstra S, Leban J, Ammendola A. 4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2010 Oct;16(10):1763-77.
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