| CAS NO: | 14919-35-8 |
| 包装: | 50mg |
| 市场价: | 3680元 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 323.86 |
| Cas No. | 14919-35-8 |
| Formula | C15H30ClNO4 |
| Solubility | ≥10.06 mg/mL in EtOH; ≥12.6 mg/mL in DMSO; ≥34.05 mg/mL in H2O |
| Chemical Name | (S)-3-carboxy-N,N,N-trimethyl-2-(octanoyloxy)propan-1-aminium chloride |
| Canonical SMILES | O=C(CCCCCCC)O[C@@H](CC(O)=O)C[N+](C)(C)C.[Cl-] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
(±)-Octanoylcarnitine chloride is a homolog of acetylcarnitine chloride. Acylcarnitines, the acetyl derivatives of carnitine, are important intermediates in lipid metabolism, required for the transport of long-chain fatty acids into mitochondria for β-oxidation and ATP production, and for the removal of excess short-chain and medium-chain fatty acids. (±)-Octanoylcarnitine has been shown to decrease the oxidation rate of the branched-chain 2-oxo acids 4-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate in isolated rat muscle mitochondria in the presence of carnitine, but octanoyl-L-carnitine increases oxidation of 4-methyl-2-oxopentanoate in the absence of carnitine. In addition, (±)-octanoylcarnitine, along with malate, has been used as a mitochondrial respiration substrate to evaluate the effect of creatine on the respiration rate of isolated rat cardiac fibers exposed to increasing concentrations of ADP.
References:
1. Zhang Y, Ma Q, Bai X. Effects of dietary acetyl-L-carnitine on meat quality and lipid metabolism in arbor acres broilers. Asian-Australasian Journal of Animal Sciences, 2010, 23(12): 1639-1644.
2. Veerkamp JH, van Moerkerk HT, Wagenmakers AJ. Interaction of short-chain and branched-chain fatty acids and their carnitine and CoA esters and of various metabolites and agents with branched-chain 2-oxo acid oxidation in rat muscle and liver mitochondria. International Journal of Biochemistry, 1985, 17(9): 967-974.
3. Toleikis A, Trumbeckaite S, Liobikas J, et al. Fatty Acid Oxidation and Mitochondrial Morphology Changes as Key Modulators of the Affinity for ADP in Rat Heart Mitochondria. Cells, 2020, 9(2): 340.
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