| CAS NO: | 26993-30-6 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 379.48 |
| Cas No. | 26993-30-6 |
| Formula | C18H38NO5P |
| Solubility | ≤4 mg/ml in 0.3M NaOH |
| Chemical Name | (2S,3R,E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate |
| Canonical SMILES | O[C@H](/C=C/CCCCCCCCCCCCC)[C@H](COP(O)(O)=O)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Sphingosine-1-phosphate is an endogenous second messenger that involved in cell proliferation and survival and is a ligand for S1PR1 [1] [2].
Sphingosine-1-phosphate receptor 1 (S1PR1), also known as endothelial differentiation gene 1 (EDG1), is a G-protein-coupled receptor for sphingosine-1-phosphate (S1P) and is involved in regulating endothelial cell cytoskeletal structure, capillary-like network formation, migration and vascular maturation.
Sphingosine-1-phosphate is an endogenous second messenger and a ligand for S1PR1. In endothelial cells, S1P (1-20 μM) induced EDG-l-dependent morphogenesis. In HEK293EDG-1 cells, S1P bound to S1PR1 with Kd value of 8.1 nM in a time-dependent way. In cells transfected with EDG-l, S1P activated ERK-1 and ERK-2 via EDG-1. S1P existed in platelets and released through platelet activation [2]. In human embryonic kidney (HEK) cells, S1P significantly increased [Ca2+]i with EC50 value of 2 nM in a pertussis toxin-sensitive way and inhibited cAMP accumulation induced by forskolin. Also, S1P increased the binding of guanosine 5’-3-O-(thio)triphosphate to cell membranes. In guinea pig atrial myocytes, S1P at the extracellular face activated Gi protein-regulated inwardly rectifying potassium channels [3]. S1P inhibited programmed cell death mediated by ceramide [4].
References:
[1]. Olivera A, Spiegel S. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature, 1993, 365(6446): 557-560.
[2]. Lee MJ, Van Brocklyn JR, Thangada S, et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science, 1998, 279(5356): 1552-1555.
[3]. van Koppen C, Meyer zu Heringdorf M, Laser KT, et al. Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J Biol Chem, 1996, 271(4): 2082-2087.
[4]. Cuvillier O, Pirianov G, Kleuser B, et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature, 1996, 381(6585): 800-803.
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