| CAS NO: | 922-32-7 |
| 包装: | 5g |
| 市场价: | 650元 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 255.08 |
| Cas No. | 922-32-7 |
| Formula | C4H8N3Na2O5P |
| Solubility | insoluble in ETOH; insoluble in DMSO; ≥54.6 mg/mL in H2O |
| Chemical Name | sodium (E)-(amino((carboxymethyl)(methyl)amino)methylene)phosphoramidate |
| Canonical SMILES | OC(CN(C)/C(N)=N/P([O-])([O-])=O)=O.[Na+].[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Phosphocreatine (also known as creatine phosphate) disodium salt is a phosphorylated creatine molecule that may serve as a quickly accessible reserve of high-energy phosphates in skeletal muscle, myocardium as well as the brain. Phosphocreatine can offer a phosphate group to ADP for ATP synthesis, or conversely, excess ATP can be used to convert creatine to creatine phosphate via creatine kinase. Thus, phosphocreatine disodium salt could be used as a substrate for the determination of creatine kinase, and is used to regenerate ATP during skeletal muscle contraction.
References:
1. Wallimann T, Wyss M, Brdiczka D, et al. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochemistry Journal, 1992, 281: 21-40.
2. Feldman EB. Creatine: a dietary supplement and ergogenic aid. Nutrition Reviews, 1999, 57(2): 45-50.
3. Qaed E, Wang J, Almoiliqy M, et al. Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxidative Medicine and Cellular Longevity, 2019, 2019: 6521218.
| Cell experiment:[3] | |
Cell lines | H9C2 cells |
Reaction Conditions | 5 ~ 20 mM phosphocreatine for 2 h incubation |
Applications | Phosphocreatine was found to provide a significant protective effect in H9C2 cells injured by exposure to methylglyoxal. Moreover, phosphocreatine at different concentrations (5 ~ 40 mM) has no lethality on normal H9C2 cells. |
| Animal experiment:[3] | |
Animal models | Wistar male rats with type 1 diabetes mellitus |
Dosage form | 20 or 50 mM Administered intravenously once daily for 12 weeks |
Applications | In diabetic rats, phosphocreatine significantly reduced heart sizes, reduced blood glucose levels, and improved the striation of myocardial fibers arranged regularly in treated groups. Phosphocreatine offered a defensive impact against diabetic cardiomyopathy. |
Note | The technical data provided above is for reference only. |
References: 1. Wallimann T, Wyss M, Brdiczka D, et al. Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochemistry Journal, 1992, 281: 21-40. 2. Feldman EB. Creatine: a dietary supplement and ergogenic aid. Nutrition Reviews, 1999, 57(2): 45-50. 3. Qaed E, Wang J, Almoiliqy M, et al. Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxidative Medicine and Cellular Longevity, 2019, 2019: 6521218. | |
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