p-Chlorophenylalanine

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CAS NO:	7424-00-2
包装:	1g
市场价:	500元

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at RT
M.Wt	199.64
Cas No.	7424-00-2
Formula	C₉H₁₀ClNO₂
Solubility	insoluble in EtOH; insoluble in DMSO; ≥4.58 mg/mL in H2O with gentle warming and ultrasonic
Chemical Name	(R)-2-amino-3-(4-chlorophenyl)propanoic acid
Canonical SMILES	ClC1=CC=C(C=C1)C[C@H](C(O)=O)N
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

p-Chlorophenylalanine is a selective irreversible inhibitor of tryptophan hydroxylase. Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine). p-Chlorophenylalanine can deplete endogenous serotonin levels.

p-Chlorophenylalanine significantly attenuates pulmonary vascular remodeling and lung inflammation induced by MCT (Wild Lily), inhibits Tph-1 and SERT, MMP-2/ -9, TIMP-1/-2. Expression of IL-1β, TNF-α, ICAM-1. p-Chlorophenylalanine inhibits 5-HT by inhibiting Tph-1, regulating SERT and serotonin downstream signaling pathways.

Reference:

[1]. Bai Y, Wang H, Liu M, et al. 4-Chloro-DL-phenylalanine protects against monocrotaline-induced pulmonary vascular remodeling and lung inflammation. International Journal of Molecular Medicine, 2014, 33(2): 373-382.