[Leu5]-Enkephalin

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[Leu5]-Enkephalin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	58822-25-6
包装:	25mg
市场价:	1100元

产品介绍

化学性质

Physical Appearance	A solid
Storage	Desiccate at -20°C
M.Wt	555.63
Cas No.	58822-25-6
Formula	C₂₈H₃₇N₅O₇
Solubility	≥54.6 mg/mL in H2O; ≥54.8 mg/mL in EtOH; ≥55.6 mg/mL in DMSO
Chemical Name	(2S,5R,14S)-14-amino-5-benzyl-15-(4-hydroxyphenyl)-2-isobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid
Canonical SMILES	O=C([C@@H](CC1=CC=CC=C1)NC(CNC(CNC([C@H](CC(C=C2)=CC=C2O)N)=O)=O)=O)N[C@H](C(O)=O)CC(C)C
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

[Leu5]-Enkephalin, naturally present in mammalian brain, is one of the endogenous pentapeptides with morphine-like properties. [Leu5]-Enkephalin exhibits agonistic actions at both the δ- and μ-opioid receptors, with substantially greater preference for the former, but shows little effect on the κ-opioid receptor. In humans, the δ-opioid receptor is most heavily expressed in basal ganglia and neocortical regions, and associated with pain, depression, as well as learning and memory. [Leu5]-Enkephalin, along with the other endogenous pentapeptide, [Met5]-enkephalin, have been found to behave as potent, yet short-lived opiatesin vivo.

References:

1. Sengul G, Watson C. Chapter 6 - Spinal Cord: Regional Anatomy, Cytoarchitecture and Chemoarchitecture. The Human Nervous System (Third Edition), 2012.

2. Peppin JF, Raffa RB. Delta opioid agonists: a concise update on potential therapeutic applications. Journal of Clinical Pharmacy and Therapeutics, 2015, 40(2): 155-166.

3. Meunier JC, Moisand C. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Letters, 1977, 77(2): 209-213.

4. DiMaio J, Nguyen TM, Lemieux C, et al. Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. Journal of Medicinal Chemistry, 1982, 25(12): 1432-1438.

试验操作

Cell experiment:[4]
Cell lines	Mouse vas deferens
Reaction Conditions	11.4 nM [Leu5]-encephalin
Applications	[Leu5]-Encephalin inhibited electrically stimulated contractions in mouse vas deferens, with an IC50 value of 11.4 nM.
Note	The technical data provided above is for reference only.
	References: 1. Sengul G, Watson C. Chapter 6 - Spinal Cord: Regional Anatomy, Cytoarchitecture and Chemoarchitecture. The Human Nervous System (Third Edition), 2012. 2. Peppin JF, Raffa RB. Delta opioid agonists: a concise update on potential therapeutic applications. Journal of Clinical Pharmacy and Therapeutics, 2015, 40(2): 155-166. 3. Meunier JC, Moisand C. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Letters, 1977, 77(2): 209-213. 4. DiMaio J, Nguyen TM, Lemieux C, et al. Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. Journal of Medicinal Chemistry, 1982, 25(12): 1432-1438.