6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil.
| Cas No. | 120013-56-1 |
| 别名 | 6-O-去甲基多奈哌齐 |
| Canonical SMILES | O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(O)C=C41 |
| 分子式 | C23H27NO3 |
| 分子量 | 365.5 |
| 溶解度 | Chloroform: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 µM in HEK293 cells expressing hERG). |
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