Amastatin (hydrochloride) 是一种缓慢、紧密结合、竞争性氨肽酶 (AP) 抑制剂，对气单胞菌氨肽酶、胞质亮氨酸氨肽酶、微粒体氨肽酶的 Ki 值为 0.26 nM、30 nM、52 nM。
| Cas No. | 100938-10-1 |
| 别名 | 氨肽酶抑制剂盐酸盐 |
| Canonical SMILES | CC(C)[C@H](NC([C@@H](NC([C@@H](O)[C@H](N)CC(C)C)=O)C(C)C)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O.Cl |
| 分子式 | C21H38N4O8•HCl |
| 分子量 | 511 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 2 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 µg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 µM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin. |
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